Z01 CP010136-02320 (Z01) | |||
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Title | Oral and pharyngeal cancer in Puerto Rico | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Silverman, Debra | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $8,155 | Project Dates | 03/01/1993 - N/A |
Fiscal Year | 2008 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Buccal Cavity (100.0%) Head and Neck (100.0%) |
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Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors |
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Abstract | |||
In a case-control investigation in Puerto Rico, we found that the risk of oral cancer associated with drinking alcohol was magnified among persons who had the ADH31-1 genotype, a trait associated with efficient metabolism of alcohol to the toxic metabolite, acetaldehyde. Other genetic factors associated with metabolism of alcohol and tobacco-related compounds are currently under investigation. We also found that the excess risks for oral cancer in Puerto Rico are largely explained by patterns of alcohol and tobacco use. Smoking filtered, as opposed to non-filtered, cigarettes did not alter risk, while cessation of alcohol and tobacco use appeared to reduce risk only gradually. |